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Base of study : Even moderate drinking might be bad for aging brains

Here’s one more reason to think before you drink: even a modest amount of booze might be bad for aging brains.

A new study published Tuesday in the medical journal BMJ says moderate drinkers were more likely than abstainers or light drinkers to develop worrisome brain changes that might signal eventual memory loss. They also were more likely to show rapid slippage on a language test, though not on several other cognitive tests.

Moderate drinking in the British study was defined at a level that, in the United States, would equal 8 to 12 small glasses of wine, bottles of beer or shots of liquor each week.

“Many people drink this way,” and previous studies have suggested they might actually be helping their brains, said lead researcher Anya Topiwala, a clinical lecturer in psychiatry at the University of Oxford.

The new study casts doubt on that idea, suggesting harm from moderate drinking and no help from light drinking, she said. The study did not look at heavy, abusive drinking, but that already is firmly linked with brain damage and dementia, she noted

For the study, she and her colleagues examined three decades of records from 527 British civil servants who are part of a long-running health study. The volunteers, who are predominantly white middle class men, took brief cognitive tests and recorded their drinking histories on multiple occasions, starting at an average age of 43.

The researchers brought the volunteers in for brain scans, repeated the brief cognitive tests and administered a more extensive battery of memory and thinking tests.

For the most part, light to moderate drinkers and abstainers performed similarly when they were matched for age, sex, education, social class, physical activity, smoking and other factors.

There was one exception: moderate to heavy drinkers showed more rapid declines on a language fluency test. The test gives people a minute to name as many words as they can, beginning with a particular letter.

The brain scans also showed differences. Most notably, the heaviest drinkers were most likely to have clear shrinkage of a part of the brain called the hippocampus, a change that can precede or accompany dementia. Even moderate drinkers were three times more likely than abstainers to show hippocampal shrinkage, the researchers said.

An important caveat: The study is observational, so it cannot prove cause and effect. It is possible that frequent drinkers had other things in common that accounted for the brain and language changes.

Still, at this point, “I wouldn’t recommend light to moderate drinking as a strategy to avoid cognitive decline,” Topiwala said. And, she said, it’s not clear how much drinking might be safe from a brain health standpoint.

U.S. guidelines recommend no more than 1 drink a day for women and 2 drinks a day for men, citing uncertain heart benefits and known risks, including traffic accidents, violence, and a link with breast cancer. Many countries, including the United Kingdom, recommend lower limits for men.

There is no health reason for anyone who does not drink to take up drinking, said Brian Downer, an assistant professor in the division of rehabilitation sciences at the University of Texas Medical Branch at Galveston. The new research is a good reminder that even moderate drinking can have health consequences, said Downer, who was not involved in the study.

But, he said, more research on cognitive effects is needed. And none of the findings suggests a need for total abstinence, he said. “You don’t have to feel that you have to completely quit drinking to have a healthy lifestyle.”


Drinking even moderate amounts of alcohol is linked to changes in brain structure and an increased risk of worsening brain function, scientists said on Tuesday.

In a 30-year study that looked at the brains of 550 middle-aged heavy drinkers, moderate drinkers and teetotallers, the researchers found people drank more alcohol had a greater risk of hippocampal atrophy – a form of brain damage that affects memory and spatial navigation.

People who drank more than 30 units a week on average had the highest risk, but even those who drank moderately – between 14 and 21 units a week – were far more likely than abstainers to have hippocampal atrophy, the scientists said.

“And we found no support for a protective effect of light consumption on brain structure,” they added.

The research team – from the University of Oxford and University College London – said their results supported a recent lowering of drinking limit guidelines in Britain but posed questions about limits recommended in the United States.

US guidelines suggest that up to 24.5 units of alcohol a week are safe for men, but the study found increased risk of brain structure changes in just 14 to 21 units a week.

A unit is defined as 10 millilitres (ml) of pure alcohol. There are roughly two in a large beer, nine in a bottle of wine and one in a 25 ml spirit shot.

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